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Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1

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Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1

China Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1 supplier
Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1 supplier Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1 supplier

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Product Details:

Place of Origin: China
Brand Name: wumeitech
Certification: ISO 9001
Model Number: 120511-73-1

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: disguised packing
Delivery Time: 3-7 days
Payment Terms: T/T, Western Union, Money Gram, Bitcoin, Bank transfer
Supply Ability: 800kg/month
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Detailed Product Description
CAS No: 120511-73-1 Assay: 99%
Molecular Weight: 293.37 Molecular Formula: C17H19N5
Appearance: White To White Crystalline Powder Payment Terms: T/T, Western Union, Money Gram, Bitcoin, Bank Transfer
Sample: Yes Price: Negotiable

Anastrozole

Synonyms:Arimidex;1-[3,5-Di-(1-Methyl-1-Cyano)-Ethyl]-Benzyl-1,2,4-Triazole;

Anastrozole;tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile;ZD-1033

CAS:120511-73-1

MF: C17H19N5

MW:293.37

Chemical properties:It can be crystallized from ethyl acetate-cyclohexane, the melting point is 81~82℃.

MP: 81-82°C

Storage Temp. :Store at RT

Usage:An aromatase inhibitor. Used as an antineoplastic.

Biological Activity:Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

Uses (1) It is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients.

(2) Its used to cure the breast cancer.

(3) Anastrozole is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients. It is an inhibitor for the triazole aromatase with a strong selectivity. It can inhibits aromatase which is prerequisite for the synthesis of pigment cells P-450 thereby blocking the biosynthesis of estrogens, and the estrogen is the essential part of the growth of breast cancer cells. Its used to cure the breast cancer, particularly suitable for postmenopausal women with advanced breast cancer who recrudescent after hormone adjuvant therapy.

ANALYSIS SPECIFICATIONS RESULTS
Assay 98.0%--102.0% 99.7%

 

CHEMICAL CONTROL

Identification

IR

HPLC

reactive

Conform with standard IR

Conform with standard HPLC

Conform

Solubility Freely soluble in methanol,acetone,ethanol and tetrahydrofuran. And very soluble in acetonitrile Complies
Melting Point 81.0 ~ 84.0℃ 82.9 ~ 83.3℃
Total Impurity 0.5%(max) 0.20%
Total unspecified impurity 0.2%(max) 0.11%
Individual unspecified impurity 0.1%(max) 0.07%
Related compound B 0.2%(max) 0.05%
Related compound C 0.2%(max) 0.02%
Related compound D 0.1%(max) 0.06%
Related compound E 0.1%(max) 0.08%
Limit Of Cyclohexane 0.08%(max) ND
Limit Of Ethylacetate 0.1%(max) 0.05%
PHYSICAL CONTROL
Description White crystalline powder Complies
Water 0.3%(max) 0.25%
Heavy Metal 0.001%(max) Complies
Residue On Ignition 0.1%(max) 0.06%
Storage Cool and dry
Shelf Life 24 months

 

Letrozole And Anastrozole:

Anastrozole is an inhibitor for the triazole aromatase with a strong selectivity. It can inhibits aromatase which is prerequisite for the synthesis of pigment cells P-450 thereby blocking the biosynthesis of estrogens, and the estrogen is the essential part of the growth of breast cancer cells. The 50% inhibitory concentration (IC50) value of anastrozole to placental aromatase is 15nmol/L.

Letrozole is used for the treatment of advanced breast cancer of postmenopausal women.It mainly applied to the second-line treatment after the failure of the anti-estrogen treatment.

 

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Anastrozole Arimidex 99% powder Anastrozole Anabolic effect enhancer CAS 120511-73-1

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