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|Molecular Weight:||329.43||Molecular Formula:||C20H27NO3|
|Appearance:||White Powder||Payment Terms:||T/T, Western Union, Money Gram, Bitcoin, Bank Transfer|
Chemical Properties:White powder
Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer.
Indications: Trilostane can inhibit 3β-dehydrogenase in the synthesis of corticosteroids, and decrease the synthesis of cortisol and aldosterone. It also can be used in the treatment of Cushing's syndrome (hypercortisolism) and primary aldosteronism. But the efficacy to treat Cushing's syndrome (hypercortisolism) is not as metyrapone. This product also has a significant role in lowering blood testosterone levels, which may be related with that its synthesis is inhibited.
The Treatment of Advanced Breast Cancer
Breast cancer is the most common type of tumor in women. Currently, for postmenopausal patients with hormone receptor-positive or unknown, clinical treatments unanimously recommend to be the preferred antiestrogen therapy, and the role of this therapy in delaying disease progression and improving survival time also has been affirmed and confirmed in numerous studies of breast cancer.
Trilostane (trade name Modrenal) developed by the biotechnology company has already been on the market. It can be used for the treatment of postmenopausal women that hormone-selective cancer has spread outside the breast. The pharmaceutical uses two ways to slow down the disease progression. For hormone-sensitive breast cancer, estrogen promotes the growth of cancer cells by acting to the two receptors. Estrogen receptor α is cancer accelerator, and estrogen receptor β is the brake. Modrenal strengthens estrogen adsorption to the estrogen receptor β, and weakens the adsorption to estrogen receptor α. Meanwhile it also acts on another loci AP1in cell DNA to reduce cell proliferation.
Breast cancer is one of hormone-dependent tumors. And estrogen is the main driving factor of the growth of breast cancer cells. Thus, one of the modern treatment of breast cancer is the major target of estrogen through inhibiting the production of estrogen or block the action of estrogen or estrogen receptor in its site of action. It has been known that estrogen receptor is only a single receptor, but recent studies have identified that there are at least two subtypes α and β. Estrogen uniting with α- estrogen can stimulate cell growth, but it uniting with β-estrogen receptor can cut α- estrogen receptors and slow the rate of cell proliferation. Research revealed that the trilostane cannot only lower the production of estrogen, but also can modulate the binding of estrogen receptors on different subtypes. And meanwhile the dual effect of α-estrogen receptor inhibitors and β-estrogen receptor appears. Finally it can block and alter the negative effect of estrogen on cancer cells. The unique mode of action of trilostane can not only set it apart from other existing anti-estrogen drugs, but also be the pharmacological basis of that it is still highly effective on breast cancer in treatment failure with other anti-estrogen therapy or resistant breast cancer.
|Test Items||Specification||Test Results|
|Appearance||white or almost white,crystalline powder||Conform|
|Solubility||Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.||Conform|
|Identification||A||The UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
|B||Infraed absorption spectrophotometry.||Conform|
|C||Chromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
|D||An orange-red color develop in methylene chloride layer.||Conform|
|E||It geves reaction (a) of sulphates.||Conform|
|Appearance of solution||Solution S is clear and not more intensely coloured than reference solution in BY6.||Conform|
|Optical rotation||negative 0.10° to +0.10°determined on solution S.||+0.01°|
|Acidity or alkalinity||NMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
|Related substances||Impurity J ≤0.20%||Conform|
|Any other impurity ≤0.30%||Conform|
|Total impurity ≤1.0%||Conform|
|Loss on drying||≤0.5%||0.30%|
|Assay(on dried basis)||98.0~101.0%||99.5%|
|Testosterone Base||Boldenone Base||MGF|
|Testosterone Acetate||Boldenone Acetate||PEG MGF|
|Testosterone Decanoate||Boldenone Propionate||CJC-1295 DAC|
|Testosterone Enanthate||Boldenone Cypionate||PT-141|
|Testosterone Isocaproate||Nandrolone Base||Melanotan-1|
|Testosterone Phenylpropionate||Nandrolone Decanoate||Melanotan-2|
|Testosterone Propionate||Nandrolone phenylprop||GHRP-2|
|Testosterone Undecanoate||Nandrolone undecylate||GHRP-6|
|Clostebol Acetate||Trenbolone Base||Oxytocin|
|Testosterone Sustanon 250||Trenbolone Enanthate||HGH 176-191|
|Methenolone Acetate||Oxymetholone / Anadrol||Selank|
|Methyldrostanolone||Oxandrolone / Anavar||BPC 157|
|Drostanolone Propionate||Stanozolol / Winstrol||Epitalon|
|Drostanolone Enanthate||Methandienone / Dianabol||Follistatin 344|
|Tamoxifen Citrate||Sildenafil citrate||MK-2866|
|Clomifene citrate||Tadalafil / Cialis||Andarine / S4|
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