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Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal

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Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal

China Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal supplier
Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal supplier Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal supplier

Large Image :  Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal

Product Details:

Place of Origin: China
Brand Name: wumeitech
Certification: ISO 9001
Model Number: USP37

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: disguised packing
Delivery Time: 3-7 days
Payment Terms: T/T, Western Union, Money Gram, Bitcoin, Bank transfer
Supply Ability: 800kg/month
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Detailed Product Description
CAS No: 107868-30-4 Assay: 99%
Molecular Weight: 329.43 Molecular Formula: C20H27NO3
Appearance: White Powder Payment Terms: T/T, Western Union, Money Gram, Bitcoin, Bank Transfer
Sample: Yes Price: Negotiable

Basic Info:

Product Name:Trilostane

Synonyms:(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal

CAS:13647-35-3

MF: C20H27NO3

MW:329.43

EINECS: 237-133-0

Chemical Properties:White powder

MP:264°C

 

Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer.

Indications: Trilostane can inhibit 3β-dehydrogenase in the synthesis of corticosteroids, and decrease the synthesis of cortisol and aldosterone. It also can be used in the treatment of Cushing's syndrome (hypercortisolism) and primary aldosteronism. But the efficacy to treat Cushing's syndrome (hypercortisolism) is not as metyrapone. This product also has a significant role in lowering blood testosterone levels, which may be related with that its synthesis is inhibited.

 

The Treatment of Advanced Breast Cancer

Breast cancer is the most common type of tumor in women. Currently, for postmenopausal patients with hormone receptor-positive or unknown, clinical treatments unanimously recommend to be the preferred antiestrogen therapy, and the role of this therapy in delaying disease progression and improving survival time also has been affirmed and confirmed in numerous studies of breast cancer.

Trilostane (trade name Modrenal) developed by the biotechnology company has already been on the market. It can be used for the treatment of postmenopausal women that hormone-selective cancer has spread outside the breast. The pharmaceutical uses two ways to slow down the disease progression. For hormone-sensitive breast cancer, estrogen promotes the growth of cancer cells by acting to the two receptors. Estrogen receptor α is cancer accelerator, and estrogen receptor β is the brake. Modrenal strengthens estrogen adsorption to the estrogen receptor β, and weakens the adsorption to estrogen receptor α. Meanwhile it also acts on another loci AP1in cell DNA to reduce cell proliferation.

Mechanism

Breast cancer is one of hormone-dependent tumors. And estrogen is the main driving factor of the growth of breast cancer cells. Thus, one of the modern treatment of breast cancer is the major target of estrogen through inhibiting the production of estrogen or block the action of estrogen or estrogen receptor in its site of action. It has been known that estrogen receptor is only a single receptor, but recent studies have identified that there are at least two subtypes α and β. Estrogen uniting with α- estrogen can stimulate cell growth, but it uniting with β-estrogen receptor can cut α- estrogen receptors and slow the rate of cell proliferation. Research revealed that the trilostane cannot only lower the production of estrogen, but also can modulate the binding of estrogen receptors on different subtypes. And meanwhile the dual effect of α-estrogen receptor inhibitors and β-estrogen receptor appears. Finally it can block and alter the negative effect of estrogen on cancer cells. The unique mode of action of trilostane can not only set it apart from other existing anti-estrogen drugs, but also be the pharmacological basis of that it is still highly effective on breast cancer in treatment failure with other anti-estrogen therapy or resistant breast cancer.

 

Test Items Specification Test Results
Appearance white or almost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform
Identification A The UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
Conform
  B Infraed absorption spectrophotometry. Conform
  C Chromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
Conform
  D An orange-red color develop in methylene chloride layer. Conform
  E It geves reaction (a) of sulphates. Conform
Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
Conform
Related substances Impurity J ≤0.20% Conform
  Any other impurity ≤0.30% Conform
  Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%

 

Product list:

Testosterone Base Boldenone Base MGF
Testosterone Acetate Boldenone Acetate PEG MGF
Testosterone Cypionate Equipoise CJC-1295
Testosterone Decanoate Boldenone Propionate CJC-1295 DAC
Testosterone Enanthate Boldenone Cypionate PT-141
Testosterone Isocaproate Nandrolone Base Melanotan-1
Testosterone Phenylpropionate Nandrolone Decanoate Melanotan-2
Testosterone Propionate Nandrolone phenylprop GHRP-2
Testosterone Undecanoate Nandrolone undecylate GHRP-6
Methyltestosterone Nandrolone cypionate Ipamorelin
Formestane Nandrolone propionate Hexarelin
Oral Turinabol Tibolone Sermorelin
Clostebol Acetate Trenbolone Base Oxytocin
Fluoxymesterone Trenbolone Acetate TB500
Testosterone Sustanon 250 Trenbolone Enanthate HGH 176-191
Mestanolone Methyltrienolone Triptorelin
Stanolone Trenbolone Hexa Tesamorelin
Mesterolone 7-keto DHEA Gonadorelin
Methenolone Enanthate DHEA DSIP
Methenolone Acetate Oxymetholone / Anadrol Selank
Methyldrostanolone Oxandrolone / Anavar BPC 157
Drostanolone Propionate Stanozolol / Winstrol Epitalon
Drostanolone Enanthate Methandienone / Dianabol Follistatin 344
Tamoxifen Citrate Sildenafil citrate MK-2866
Clomifene citrate Tadalafil / Cialis Andarine / S4
Toremifene citrate Vardenafil GW501516
Exemestane Avanafil RAD140
Anastrozole   SR9009
     
Letrozole Finasteride YK11
Androstadiendione Yohimbine HCL MK-677
Androstenedione Eplerenone LGD4033

 

Why WUMEITECH?

  • Professional pharmaceutical production company in China.
  • Accomplished R & D departments.
  • Highest quality finish products and best price.
  • Vast product range from steroid powder to steroid liquid.
  • First-class service and high successful delivery rate.
  • Highly advanced processing units and dexterous workforce.

 

We are a reliable supplier of raw steroid in China area of many years.
Our products have exported to USA, Greece, Spain, UK, Australia etc.
We are a experienced partner to send the steroid safely.

So we hope to cooperate with you to realize mutual benefit and achieve success.

 

Trilostane powder SERMs Steroids CAS 13647-35-3 for breast cancer modrenal

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