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What is the Amino Acid Sequence of IGF-1 LR3
The amino acid sequence (three letter) is Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala
Receptor Grade vs Media Grade IGF-1 LR3
Genuine Receptor Grade LR3 IGF-I is a high quality research reagent for use in studies on cell growth, IGF receptors and IGF binding proteins and is more potent than rH IGF-1 and Media Grade IGF-1 LR3 both in vivo and in vitro due to the drastic increase in biological activity (stronger affinity for binding with the IGF receptor) and high-level purity. This combination of increased biological activity and purity is what sets Receptor Grade IGF-1 LR3 apart from standard IGF-1. Media grade LR3 IGF-I is more commonly used in commercial cell culture vs mammalian. It can also be used as a research reagent at an economical cost to enable studies where biological potency is of less value and higher quantities are required. To maximize results in an animal-based cell study or production Receptor Grade IGF-1 Long R3 should be used exclusively.
IGFB Binding and Increased Biological Activity
By resisting IGFBP-binding, IGF-1 LR3 has a greater physiologic effect than IGF-1 does. The longer duration of action allows for smaller amounts to be used with the same effects. Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke. Most studies concerning the effects of IGF-1 derivatives have been carried out in animal models, with little to no data available for humans.
Insulin Like Growth Factor Receptor Interactions
IGF-1 Long R3 binds to at least two cell surface receptors: IGF-1R and the insulin receptor. The IGF-1 receptor is referred to as the "physiologic" receptor because IGF-1 binds to it with significantly higher affinity (approximately 100 times higher) than it does to the insulin receptor. By binding to IGF-1R, IGF-1 can affect metabolism, cell growth (hypertrophy), differentiation and cell division (hyperplasia), prevention of cell death (apoptosis), normal development, and even malignant growth. IGF-1R has been implicated in several different types of cancer include breast, prostate, and lung cancer. IGF-1 also binds to the insulin receptor and activates it, thereby encouraging cells to take up glucose from the blood stream. The effects of IGF-1 on muscle cells are three-fold. Firstly, IGF-1 encourages hyperplasia, or an increase in the number of muscle cells. Secondly, IGF-1 has a strong effect on skeletal muscle - In regards to the life span of satellite cells. Satellite cells support muscle cells, providing them with needed nutrients and helping them to operate efficiently. By increasing the lifespan of these cells, IGF-1 helps to increase their number with muscle tissue. Finally, IGF-1 encourages differentiation of myoblasts, which is to say that it encourages the conversion of stem cell progeny from nonspecific pluripotent stem cells into dedicated muscle tissue. In this way, IGF-1 increases the rate of muscle development by increasing the rate at which generic stem cells are converted to muscle cells.
|Testosterone Base||Boldenone Base||MGF|
|Testosterone Acetate||Boldenone Acetate||PEG MGF|
|Testosterone Decanoate||Boldenone Propionate||CJC-1295 DAC|
|Testosterone Enanthate||Boldenone Cypionate||PT-141|
|Testosterone Isocaproate||Nandrolone Base||Melanotan-1|
|Testosterone Phenylpropionate||Nandrolone Decanoate||Melanotan-2|
|Testosterone Propionate||Nandrolone phenylprop||GHRP-2|
|Testosterone Undecanoate||Nandrolone undecylate||GHRP-6|
|Clostebol Acetate||Trenbolone Base||Oxytocin|
|Testosterone Sustanon 250||Trenbolone Enanthate||HGH 176-191|
|Methenolone Acetate||Oxymetholone / Anadrol||Selank|
|Methyldrostanolone||Oxandrolone / Anavar||BPC 157|
|Drostanolone Propionate||Stanozolol / Winstrol||Epitalon|
|Drostanolone Enanthate||Methandienone / Dianabol||Follistatin 344|
|Tamoxifen Citrate||Sildenafil citrate||MK-2866|
|Clomifene citrate||Tadalafil / Cialis||Andarine / S4|
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