Acadesine AICAR SARM Tablets For Fat Burning Cancer Effective Cas 2627-69-2

99.7% Pure Steroids Acadesine Pharma Grade Powder and AICAR SARM Pills for Fat Burning Effective CasNO.2627-69-2

Product details:

Product description
Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Function:

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Hjtc (Xiamen) Industry Co., Ltd.

Xiamen Huayongjian Biotechnology Co., Ltd.

Contacts: June & Eason

Whatsapp:+8618206063252; +8618759200098

E-mail: june@steroidpowder-hjtc.com;

eason@steroidpowder-hjtc.com

Web site:https://www.steroidpowder-hjtc.com/
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Description:

AICAR uses metabolic pathways to block certain enzymes, which allows for AMP-activated protein kinase. This can be explained to the layperson like this: once you take a substantial amount of AICAR, it tricks your body at a cellular level in to thinking that exercise has just been performed. Since the body thinks it has just done a considerable amount of exercise, the energy cycle at the cellular level starts converting fuel sources, like fatty acids, to output the energy that was thought to have been spent during exercise. This can have a direct effect on the level of endurance activity and the sustainability of that activity. Insulin sensitivity is also noted to be one action that AICAR produces, as the body will think it just went through a series of exercises. Interestingly, in animal studies with obese mice, AICAR showed all of the peptides benefits for obese diet induced mice, yet the healthy lean mice did not reap any of the benefits of insulin sensitivity or increase in glucose uptake. That being said, the application in bodybuilding does not seem very suitable, as these mechanisms are targeted for the out-of-shape and overweight, so if you are not a top level endurance athlete I just do not see the reason for using AICAR. A much better option would be Cardarine (GW-50156), as this compound is readily activated by exercise, so the need to work out or cardio would be an incentive.

Aicar Specification:

Our advantages

Quality
With our years of experience, advanced technology and continuous research, our quality is tofully meet the needs of the market to meet the requirements of customers

Delivery
when we confirmed your payment,we will pack your products within 24 hours,and we will shipping within 48 hours,tracking number and picture of parcel will be sent to you.

Price
best price will be provided to you, of course, my friend, you buy more, our price will be more affordable, we will send some gift to you

Service
Your order number and pictures will be sent to you via e-mail, we will tell you to search a single number of URLs, and we will always track your order number

Order Guide

Q1: Have your Product Quality been Approved by Third Party Lab?

A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.

Q2:How do you treat quality complaint?

A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.

Q3: Is there any discount?

A: Yes, for larger quantity, we always support with better price.

Q4:How long does it take to the goods arrived?

A:It is Depending on your location.

Q5 Do you have any reshipment policy?

A: We have good after-sale service and re-shipment policy if the parcel lose. Our long association with our clients has brought great benefits. We always take the upmost care in the packaging of our products . Our clients will confirm this as even they struggle to find them without help at times. But in spite of our best efforts it is still possible will seize a small number of packages.

In this circumstance we promise reship free to establish long term relationship.

Packaging & Delivery Process:

1.We have stock, so we can delivery quickly at the very day when receive the payment. Fast and discreet shipment could be arranged for customs pass Guaranteed.

2.Professional team and safe shipping method . We take responsibility to provide our customers with fast delivery and secure shipping.

3.We have efficient service, Any questions or problems after receiving the product, we will give you the best sevice.

After Sales Service

1. We will ship the goods within 8hrs after get your payments. If you want to cancel or change order, please tell me within 24hours after you finish the payment...So we both can make the best of the bad bargain.

2.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.

3. you can get the goods with in 4-7days usually.If the goods were lost or not received for other reasons, please contact me Immediately.

Also stock:

FAQ

1,Can i get some samples?
Yes, we can supply the free sample, but the shipping cost be paid by customer

2,How to confirm the Product Quality before placing orders?
We offer free sample,After you test the sample,you can know our quality.then place order.

3,Can you guarantee I can get my goods without any custom problem?
Yes, We have Reship Service.You can get your goods without any problem.

4,When you ship my order?
Normally within 2 to 3 days after confirming your payment

5,How about the quality guarantee period?
24 Months

6,How do you hide the products?.
Our shipping worker is very professional.They can pack various professional discreet package for hidding the products.